Congenital Abnormalities and Preterm Birth Related to Maternal Illnesses During Pregnancy von Nándor Ács/Ferenc G Bánhidy/Andrew E Czeizel

This book provides the analysis of a uniquely large, population-based data set evaluating congenital anomalies as a consequence of maternal diseases. The possible adverse birth outcomes of babies born to mothers diagnosed with important diseases have not yet been evaluated in such a material by the same method. The greatest merit of these studies is that by analyzing their data the authors managed to identify some new previously unknown associations between maternal diseases and adverse birth outcomes. The first aim of the authors was to summarize 50 years of experiences in human teratology which may help younger experts to use them. The second objective was to show the methodological weaknesses of previous studies and to recommend the use of up-to-date methods when designing new studies. A surveillance database like the one used in these studies effectively helps to monitor the most important indicators of adverse birth outcomes such as congenital anomalies, preterm births, and low birth weight, to evaluate the efficacy of medical care of pregnant women, and to detect possible causes of adverse birth outcomes in order to help in their prevention. In addition, the analysis of cost-benefit of this database showed that the benefit is much higher than cost. This book may be useful in the daily practice for obstetricians, paediatricians, general practitioners and epidemiologists, moreover it could be used in the training programmes of medical students and residents as well.

InhaltsangabeINTRODUCTION PART A. THE STUDY POPULATION AND METHODS (Andrew E. Czeizel) I. The Hungarian Congenital Abnormality Registry (HCAR) II. The Hungarian Case-Control Surveillance of Congenital Abnormalities (HCCSCA) III. Preterm birth and low birth weight newborns IV. The Budapest Monitoring System of Self-poisoning Pregnant Women PART B. RESULTS OF STUDIES AND THEIR INTERPRETATION (Nándor Ács and Ferenc Bánhidy) I. Certain infectious and parasitic diseases II. Neoplasms III. Diseases of blood and blood-forming organs IV. Endocrine, nutritional and metabolic diseases V. Mental and behavioural disorders VI. Diseases of the nervous system VII. Diseases of eye and adnexa VIII. Diseases of ear and mastoid process IX. Diseases of the circulatory system X. Diseases of the respiratory system XI. Diseases of the digestive system XII. Diseases of skin and subcutaneous tissue XIII. Diseases of the musculoskeletal system and connective tissue XIV/A. Diseases of urinary tract XIV/B. Diseases of genital organs XV. Pregnancy, childbirth and puerperium XVI. Congenital malformations, deformities and chromosomal abnormalities PART C: SUMMARY OF RESULTS AND RECOMMENDATIONS (Nándor Ács, Ferenc Bánhidy and Andrew E. Czeizel) A/ Association of maternal diseases during pregnancy with higher risk of congenital abnormalities (CAs) in their children I. High fever related maternal diseases during pregnancy and CAs in their offspring II. Confirmed associations of maternal diseases with CA III. Unexpected associations of maternal diseases during pregnancy with a higher risk of CA in their children IV. Teratogenic potential of related drugs treatment V. Maternal diseases with preventive effect of CAs VI. Primary prevention of CAs B/ Association of maternal diseases withthe higher risk of preterm birth (PB) and low birth weight (LBW) newborns I. Local causes II. Microbial causes III. Chronic maternal diseases during the study pregnancy IV. Pregnancy complications during the study pregnancy V. Prevention of PB and LBW newborns

INTRODUCTION PART A. THE STUDY POPULATION AND METHODS (Andrew E. Czeizel) I. The Hungarian Congenital Abnormality Registry (HCAR) II. The Hungarian Case-Control Surveillance of Congenital Abnormalities (HCCSCA) III. Preterm birth and low birth weight newborns IV. The Budapest Monitoring System of Self-poisoning Pregnant Women PART B. RESULTS OF STUDIES AND THEIR INTERPRETATION (Nandor Ã?cs and Ferenc Banhidy) I. Certain infectious and parasitic diseases II. Neoplasms III. Diseases of blood and blood-forming organs IV. Endocrine, nutritional and metabolic diseases V. Mental and behavioural disorders VI. Diseases of the nervous system VII. Diseases of eye and adnexa VIII. Diseases of ear and mastoid process IX. Diseases of the circulatory system X. Diseases of the respiratory system XI. Diseases of the digestive system XII. Diseases of skin and subcutaneous tissue XIII. Diseases of the musculoskeletal system and connective tissue XIV/A. Diseases of urinary tract XIV/B. Diseases of genital organs XV. Pregnancy, childbirth and puerperium XVI. Congenital malformations, deformities and chromosomal abnormalities PART C: SUMMARY OF RESULTS AND RECOMMENDATIONS (Nandor Ã?cs, Ferenc Banhidy and Andrew E. Czeizel) A/ Association of maternal diseases during pregnancy with higher risk of congenital abnormalities (CAs) in their children I. High fever related maternal diseases during pregnancy and CAs in their offspring II. Confirmed associations of maternal diseases with CA III. Unexpected associations of maternal diseases during pregnancy with a higher risk of CA in their children IV. Teratogenic potential of related drugs treatment V. Maternal diseases with preventive effect of CAs VI. Primary prevention of CAs B/ Association of maternal diseases with the higher risk of preterm birth (PB) and low birth weight (LBW) newborns I. Local causes II. Microbial causes III. Chronic maternal diseases during the study pregnancy IV. Pregnancy complications during the study pregnancy V. Prevention of PB and LBW newborns